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| 木下, 幹朗; 柚木, 恵太; 得字, 圭彦; 川原, 美香; 大庭, 潔; 弘中, 和憲; 大西, 正男; Kinoshita, Mikio; Yunoki, Keita; Tokuji, Yoshihiko; Kawahara, Mika; Ohba, Kiyoshi; Hironaka, Kazunori; Ohnishi, Masao. |
| ナガイモのガンに対する機能性を探索する目的で， 1,2- ジメチルヒドラジン投与マウスにおける大腸腺腫(ACF) 発症に与える食餌性ナガイモ粉末の効果を検証した.ナガ イモ粉末をAIN-93G標準飼料のコーンスターチ部分に 100%または50%置き換えて投与したところ，大腸腺腫の 発症が有意に抑制されたまた，加熱および非加熱の生ナ ガイモ粉末ともに同様の効果が認められた. DNAマイク ロアレイを用いて大腸での遺伝子の異同を調べたところ， ナガイモ投与群ではアポ卜ーシスを誘導する遺伝子群の増加が認められた.To clarify the physiological effects of dietary Chinese yam (Nagaimo) on colon cancer in vivo， the effects of dietary Nagaimo on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) formation in the large intestine of mice were investigated. After 8 weeks of feeding raw or boiled Nagaimo and DMH administration，DMH-induced ACF formation was found to be significantly suppressed in the large intestines of all mice. DNA microarray analysis showed that levels of apoptosis-inducing gene expression in... |
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Palavras-chave: ナガイモ 大腸腺腫 大腸ガン 1，2-ジメチルヒドラジン DNAマイクロアレイ Chinese yam (Nagaimo) aberrant crypt foci colon cancer 1; 2-dimethylhydrazine DNA microarray. |
| Ano: 2008 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2706 |
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| Liyanage, Ruvini; Nakamura, Yumi; Shimada, Ken-ichiro; Sekikawa, Mitsuo; Jayawardana, Barana Chaminda; Han, Kyu-Ho; Tomoko, Okada; Ohba, Kiyoshi; Takahata, Yoshihisa; Morimatsu, Fumiki; Fukushima, Michihiro; 福島, 道広; 島田, 謙一郎; 関川, 三男; 韓, 圭鎬. |
| The effect of porcine artery elastin on serum cholesterol level was investigated in rats fed a cholesterol-free diet. Rats were fed for 4 weeks, with a diet (ED) containing 15% casein and 5% of porcine artery elastin in comparison with a diet (CD) containing 20% casein. The total serum and non-HDL-cholesterol concentrations were lower (P<0.001) in ED-fed group than the CD-fed group at the end of the experiment. Caecal propionate concentration and Bifidobacterium and Lactobacillus population were higher (P<0.05) in ED-fed group than the CD-fed group. The results of this study suggest that porcine artery elastin could be considered as a functional dietary protein with hypocholesterolaemic ability. Favourable amino acid composition and lysine derived... |
| Ano: 2009 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2681 |
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| Liyanage, Ruvini; Minamino, Saori; Nakamura, Yumi; Shimada, Ken-ichiro; Sekikawa, Mitsuo; Sasaki, Keiko; Ohba, Kiyoshi; Jayawardana, Barana Chaminda; Shibayama, Shin-ichi; Fukushima, Michihiro; 福島, 道広; 島田, 謙一郎; 関川, 三男. |
| In this study we compared the hypocholesterolaemic ability of two potato peptide preparations in rats. Experimental groups were fed for 4 weeks, with casein as the basal diet, in comparison with two diets containing 20% potato peptide preparations PPS (Short hydrolysis preparation) and PPL (Long hydrolysis preparation). Serum total cholesterol and serum triglyceride level were lower in PPS-fed group compared with CN-and PPL-fed groups. Lower non-HDL cholesterol level (P<0.05) in both PPS-and PPL-fed groups, was followed by higher neutral sterol excretion, and higher hepatic LDL-R and SR-B1 mRNA level than the control. Hepatic SREBP-2 and HMG-CoA reductase mRNA level were higher in PPL-fed group compared with the CN-fed group (P<0.05). Caecal total... |
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Palavras-chave: Potato peptide; Cholesterol; Short chain fatty acid; Faecal steroid; Hepatic gene; Rat. |
| Ano: 2010 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2682 |
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| Ruvini, Liyanage; Hashimoto, Naoto; Han, Kyu-Ho; Kajiura, Teppei; Watanabe, Shoko; Shimada, Ken-ichiro; Sekikawa, Mitsuo; Ohba, Kiyoshi; Fukushima, Michihiro. |
| We examined the physiological importance of bovine dietary proteins in rats fed diets prepared from bovine Achilles’tendons and arteries. Rats were fed for 4 weeks, with 20% casein diet (CON), in comparison with two diets containing 15% casein and 5% of either bovine Achilles’ tendons (AC) or arteries (AR) protein preparations. The serum total cholesterol concentration and non-HDL cholesterol level in the AR fed group were significantly lower (P<0.05) than those in the CON fed group at the end of the 4 week feeding period. The hepatic mRNAs were measured, and the HMG-CoA reductase mRNA level was significantly lower (P<0.05) in AR fed group compared to CON fed group. Total hepatic cholesterol concentration, in rats fed AC was significantly... |
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Palavras-chave: Bovine Dietary proteins; Serum lipids; Dietary Fibres; Hepatic mRNAs. |
| Ano: 2007 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/745 |
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| 木下, 幹朗; 柚木, 恵太; 得字, 圭彦; 川原, 美香; 大庭, 潔; 弘中, 和憲; 大西, 正男; Kinoshita, Mikio; Yunoki, Keita; Tokuji, Yoshihiko; Kawahara, Mika; Ohba, Kiyoshi; Hironaka, Kazunori; Ohnishi, Masao. |
| 食餌性ナガイモの大腸腺腫発症に与える効果を他のイモ類と比較しつつ，1，2-ジメチルヒドラジン投与マウスを用いて調べるとともに，ナガイモを利用した商品モデル（ナガイモ入り青汁）の効果についても検証した．その結果，ナガイモ以外のイモ類においても上記の実験動物モデルにおいて大腸腺腫抑制効果が観察されたが，腺腫数の平均はナガイモ群が一番低かった．また，商品モデルであるナガイモ入り青汁ついても腺腫抑制効果が観察された．The dietary effects of Chinese yam，nagaimo (Dioscorea opposita Thunb.)，on 1，2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) formation in the large intestine of mice were investigated and compared with those of other potato species. Potato consumption was found to significantly suppress ACF formation in the large intestines of all mice treated with DMH. Suppression of ACF formation was most remarkable in the nagaimo group. Moreover， the commercial product (aojiru) containing nagaimo powder also suppressed ACF formation. |
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Palavras-chave: ナガイモ 大腸腺腫 大腸ガン 1; 2-ジメチルヒドラジン 青汁 Chinese yam (nagaimo) aberrant crypt foci colon cancer 1; 2-dimethylhydrazine leaf juice (aojiru). |
| Ano: 2009 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2709 |
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